Monitoring tacrolimus whole blood concentrations
نویسندگان
چکیده
منابع مشابه
Clinical utility of monitoring tacrolimus blood concentrations in liver transplant patients.
The relationship between the dose of tacrolimus, trough tacrolimus blood concentration, and selected clinical endpoints (acute rejection, nephrotoxicity, and other toxicities) were examined in a prospective, multicenter clinical trial to validate the use of an enzyme-linked immunosorbent assay (ELISA) for monitoring whole-blood concentrations of tacrolimus in liver transplant patients. A total ...
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tests requiring EDTA tubes are or#{149} Day 0 represents the day that the sample was aliquoted and the aliquots were placed at the indicated dered simultaneously. Although we temperatures. Onginalvalues,obtained 0-5 days prior to aliquoting, were all the same as the day 0 value. speciQy that these specimens be shipped on solid 002, samples are often at ambient temperature during All samples wer...
متن کاملAnalysis of tacrolimus blood concentrations in renal transplant patients.
This study aimed to 1) analyze the results of tacrolimus blood concentration monitored in patients after renal transplantation, 2) observe and establish an optimal therapeutic window for patients, and 3) provide evidence for the clinical and rational use of drugs. Tacrolimus blood concentration was determined by enzyme-linked immunosorbent assay. A total of 1824 cases were obtained from the mon...
متن کاملRoutine clinical monitoring of sirolimus (rapamycin) whole-blood concentrations by HPLC with ultraviolet detection.
During phase I/II clinical trials of sirolimus (rapamycin; SRL), therapeutic drug monitoring was performed with a multistep liquid-liquid extraction of 1-mL aliquots of whole blood followed by reversed-phase HPLC with ultraviolet detection. Blood was sampled according to a standardized protocol and clinical status. SRL concentrations were interpolated from calibration curves with a linear range...
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An improved protamine-sensitive electrode based on a polymeric membrane doped with the charged ion exchanger dinonylnaphthalenesulfonate (DNNS) is used for monitoring heparin concentrations in whole blood. The electrode exhibits significant nonequilibrium potentiometric response to polycationic protamine over the concentration range of 0.5-20 mg/L in undiluted whole-blood samples. The sensor ca...
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ژورنال
عنوان ژورنال: Russian Journal of Transplantology and Artificial Organs
سال: 2020
ISSN: 2412-6160,1995-1191
DOI: 10.15825/1995-1191-2020-2-165-170